Highly Efficient, One Pot Synthesis and Oxidation of Hantsch 1,4-Dihydropyridines Mediated by Iodobenzene Diacetate (III) Using Conventional Heating, Ultrasonic and Microwave Irradiation

• 作者: Deepak Wadhwa Khalid Hussain
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: DIHYDROPYRIDINES IODOBENZENE DIACETATE ULTRASONIC Microwave One-Pot Formylpyrazoles
• 年，卷（期）: yjhxgjqkyw_2014,（3）
• 页码范围: 174-181
• 页数: 8页
• 分类号: O6

摘要

A mild, general, convenient, and efficient one-pot synthesis of 4-arylpyridines (4) is described using conventional heating, ultrasound and microwave irradiation. Aryl aldehydes (2) were efficiently condensed with ethylacetoacetate (1) and ammonium acetate in acetonitrile to give dihydropyridine intermediates (4). The latter underwent a smooth Iodobenzene Diacetate (III) mediated aromatization reaction in the same pot to afford 4-arylpyridines (4) in good to excellent yields.