Regulation and function of signal transducer and activator of transcription 3

• 作者: Qian-Rong Qi Zeng-Ming Yang
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: SIGNAL TRANSDUCER and ACTIVATOR of TRANSCRIPTION 3 PHOSPHORYLATION ACETYLATION SIGNAL pathway Tumor
• 年，卷（期）: 2014,（2）
• 页码范围: 231-239
• 页数: 9页
• 分类号: R730.231

摘要

Signal transducer and activator of transcription 3(STAT3), a member of the STAT family, is a key regulator of many physiological and pathological processes. Significant progress has been made in understanding the transcriptional control, posttranslational modification, cellular localization and functional regulation of STAT3. STAT3 can translocate into the nucleus and bind to specific promoter sequences, thereby exerting transcriptional regulation. Recent studies have shown that STAT3 can also translocate into mitochondria, participating in aerobic respiration and apoptosis. In addition, STAT3 plays an important role in inflammation and tumorigenesis by regulating cell proliferation, differentiation and metabolism. Conditional knockout mouse models make it possible to study the physiological function of STAT3 in specific tissues and organs. This review summarizes the latest advances in the understanding of the expression, regulation and function of STAT3 in physiological and tumorigenic processes.