Use of Ultrasound and Microwave Irradiation for Clean and Efficient Synthesis of 3,3’-(Arylmethylene)bis (2-hydroxynaphthalene-1,4-dione) Derivatives

• 作者: Aldo S. de Oliveira Inês M. C. Brighente Luana C. Llanes Ricardo J. Nunes Rosendo A. Yunes
• 来源期刊: 绿色与可持续化学(英文)
• 学科: 化学
• 关键词: 2-Hydroxy-1 4-naphthoquinone 3 3’-(Arylmethylene)bis(2-hydroxynaphthalene-1 4-dione) DERIVATIVES Green Chemistry
• 年，卷（期）: 2014,（4）
• 页码范围: 177-184
• 页数: 8页
• 分类号: O6

摘要

Nine 3,3’-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives were synthesized through the reaction between 2-hydroxy-1,4-naphthalen-1,4-dione and different aromatic alde-hydes in water applying ultrasonic irradiation for 5 min at room temperature and microwave irradiation for 15 min at 70°;C. Two of the nine derivatives, compounds 3-e and 3-i, obtained from 3-bromo-hydroxybenzaldehyde and 5-methylfuran-2-carbaldehyde, respectively, are previously unpublished. The structures of all compounds were established on the basis of their spectral data and mass analysis. The attractive features of this synthesis protocol include mild conditions, high atom-economy and excellent yields with the elimination of water as the only by-product.