Protein kinases are potential targets to treat inflammatory bowel disease

• 作者: Lei Yang Yutao Yan
• 来源期刊: 世界胃肠药理与治疗学杂志：英文版（电子版）
• 学科: 医学
• 关键词: Inflammatory BOWEL disease Protein ki-nase Barrier function MICROBIOTA GENETICS
• 年，卷（期）: 2014,（4）
• 页码范围: 209-217
• 页数: 9页
• 分类号: R574

摘要

Protein kinases play a crucial role in the pathogenesis of inflammatory bowel disease(IBD), the two main forms of which are ulcerative colitis and Crohn’s dis-ease. In this article, we will review the mechanisms of involvement of protein kinases in the pathogenesis of and intervention against IBD, in terms of their effects on genetics, microbiota, mucous layer and tight junc-tion, and the potential of protein kinases as therapeutic targets against IBD.