Life is more than a computer running DNA software

• 作者: Frantiek Baluka Guenther Witzany
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 生物学
• 关键词: DNA GENOME Information LIFE NON-CODING RNA Synthetic BIOLOGY Virus
• 年，卷（期）: 2014,（3）
• 页码范围: 275-278
• 页数: 4页
• 分类号: Q523

摘要

In his recent interview for the Guardian Craig Venter is elaborating about a household appliance for the future, Digital Biological Converter(DBC). Current prototype, which can produce DNA, is a box attached to the computer which receives DNA sequences over the internet to synthesize DNA; later in future also viruses, proteins, and living cells. This would help the household members to produce, e.g., insulin, virus vaccines or phages that fight antibiotic resistant bacteria. In more distant future, Craig Venter’s hope is that the DBC will generate living cells via so-called 'Universal Recipient Cell'. This platform will allow digitally transformed genomes, downloaded from the internet, to form new cells fitted for the particular needs such as therapeutics, food, fuel or cleaning water. In contrast to this, the authors propose that DNA sequences of genomes do not represent 1:1 depictions of unequivocal coding structures such as genes. In light of the variety of epigenetic markings, DNA can store a multitude of further meanings hidden under the superficial grammar of nucleic acid sequences.