Simple Reduction of Hydantoins with Sodium Borohydride

• 作者: Emiko Shibuta Jun-Ichi Yamaguchi Yoshie Oishi
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: HYDANTOIN REDUCTION IMIDAZOLIDINONE
• 年，卷（期）: 2014,（5）
• 页码范围: 286-291
• 页数: 6页
• 分类号: O6

摘要

The reduction of various hydantoins with sodium borohydride gave the corresponding 4-hydroxy- 2-imidazolidinones in high yields. In contrast, reduction employing a boron trifluoride etherate-sodium borohydride system generated 2-imidazolidinones. In both reductions, the reactivity of the hydantoin was dependent on its substituents. The Lewis acid-promoted reactions of a 4-hydroxy-2-imidazolidinone with nucleophiles were also investigated.