The Role of CD4+ and CD8+ T-Cells during Angiostrongylus vasorum Infection in Dogs

• 作者: Ana Paula Peconick Debora Negr?o-Correa Joziana Muniz de Paiva Bar?ante Kenneth Gollob Lis Ribeiro do Valle Antonelli Ricardo Toshio Fujiwara Silvio Divino de Oliveira Junior Thales Augusto Bar?ante Thiago Pasqua Narciso Vitor Márcio Ribeiro Walter dos Santos Lima
• 来源期刊: 动物科学期刊(英文)
• 学科: 医学
• 关键词: Citometria ANGIOSTRONGYLIASIS Brochoalveolar LAVAGE
• 年，卷（期）: 2014,（5）
• 页码范围: 285-290
• 页数: 6页
• 分类号: R73

摘要

A determinant factor in the pathology of canine angiostrongylosis seems to be related to the location of the parasite in the definitive host. Their presence inside the arteries and its branches, promoting mechanical and metabolic action on the wall of the vessels, may alter its homeostasis. Bronchoalveolar lavage (BAL) is a procedure that retrieves cells and other elements from de lungs for evaluation, and helps in the diagnosis of many pulmonary diseases. The aim of this study was to evaluate CD4+/CD8+ lymphocyte profile during the infection by Angiostrongylus vasorum, using cells retrieved using BAL. The identification of subpopulations of T lymphocytes by evaluating the co-expression of CD4 and CD8 receptor proteins has shown that despite the increase in both populations, there was a predominance of CD4+ T-cells, instead of CD8+ T-cells. These increases of CD4+ T-cells associated with the increase of the ratio between CD4+/CD8+ suggest polarization of a Th2 response. However, the immune cells, signaling factors, and cytokines that mediate such immunity and how and where they act within the body remain largely undefined during angiostrongylosis.