New insight in expression, transport, and secretion of brain-derived neurotrophic factor: Implications in brainrelated diseases

• 作者: Hiroshi Kunugi Misty Richards Naoki Adachi Shingo Nakajima Tadahiro Numakawa
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: BRAIN-DERIVED NEUROTROPHIC factor Transcription TRANSPORT SECRETION NEURODEGENERATIVE DISORDERS Psychiatric DISORDERS
• 年，卷（期）: 2014,（4）
• 页码范围: 409-428
• 页数: 20页
• 分类号: R742

摘要

Brain-derived neurotrophic factor(BDNF) attracts increasing attention from both research and clinical fields because of its important functions in the central nervous system. An adequate amount of BDNF is critical to develop and maintain normal neuronal circuits in the brain. Given that loss of BDNF function has beenreported in the brains of patients with neurodegenerative or psychiatric diseases, understanding basic properties of BDNF and associated intracellular processes is imperative. In this review, we revisit the gene structure, transcription, translation, transport and secretion mechanisms of BDNF. We also introduce implications of BDNF in several brain-related diseases including Alzheimer’s disease, Huntington’s disease, depression and schizophrenia.