Uptake of Bile Acid into Calcium-Induced Alginate Gel Beads Containing <i>β</i>-Chitosan Weak Acid Salt

• 作者: Kyoko Kofuji Norihisa Nishida Ryosei Kamaguchi Yoshifumi Murata
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: β-Chitosan Bile Acid Adsorption ALGINATE Gel BEAD HYPERLIPIDEMIA
• 年，卷（期）: 2014,（4）
• 页码范围: 349-355
• 页数: 7页
• 分类号: R73

摘要

Recently, potential applications for β-chitosan (β-CS) have been examined. In the present study, calcium-induced alginate gel beads (Alg-Ca) containing weak acid salts of β-CS were prepared and examined with regard to their ability to adsorb bile acids in vitro. More than 70% of taurocholate dissolved in solution was taken up by Alg-Ca containing 100 mg β-CS, sim. ilar to the degree of uptake observed with Alg-Ca containing α-CS salt. The adsorption of bile acid was affected by the absolute amount of β-CS and/or the acid concentration of the preparation. A secondary bile acid, taurodeoxycholate, was also adsorbed by Alg-Ca containing weak acid salts of β-CS. Therefore, β-CS might be used to adsorb bile acids within the gastrointestinal tract in the same manner as an anion-exchange resin, and thus serve as a complementary means by which to prevent hyperlipidemia.