Chondrosarcoma of the Hand: A Literature Review

• 作者: Antonio Tulli Antonio Ziranu Daniele Stomeo Federica Mariotti Giulio Maccauro
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: CHONDROSARCOMA Chondrogenic TUMOUR HAND FINGER DIGIT Treatment Surgery VEGF
• 年，卷（期）: 2014,（4）
• 页码范围: 403-409
• 页数: 7页
• 分类号: R73

摘要

Chondrosarcoma (CS) is a malignant neoplasm of mesenchymal origin characterized by the formation of cartilaginous matrix by neoplastic cells. It is very variable in presentation, clinical, genetic and anatomo-pathological features. CS is more often found in the pelvis and the proximal long bones (femur, humerus). Localization to the small bones of the hand is very rare and it represents a diagnostic and therapeutic challenge. CSs are malignancies resistant to both radiation and chemotherapy . Surgical treatment is the only mean available. As opposed to CSs located elsewhere, CS of the hand is characterized by local recurrence and very low metastatic potential. In order to definitely set a diagnosis of chondrosarcoma in this region, comparison of histological and radiological findings is paramount. The principle goal of surgery shall be minimizing functional impairment. This provides the rationale for performing curettage, local adjuvant therapy and bone grafting in low-grade lesions.