Improvement of visual acuity based on optical coherence tomography patterns following intravitreal bevacizumab treatment in patients with diabetic macular edema

• 作者: Ahmed Al Habash Essam Al-Askar Haider R.Cheema
• 来源期刊: 国际眼科杂志：英文版
• 学科: 医学
• 关键词: optical COHERENCE tomography DIABETIC MACULAR EDEMA INTRAVITREAL injection BEVACIZUMAB
• 年，卷（期）: 2014,（2）
• 页码范围: 251-255
• 页数: 5页
• 分类号: R587.2

摘要

AIM:To report the visual outcome based on various patterns of optical coherence tomography(OCT)morphology in diabetic macular edema(DME),following treatment with anti-VEGF intravitreal bevacizumab(IVB)injection.METHODS:Sixty-seven consecutive subjects with centre involving DME underwent intravitreal injection of bevacizumab(1.25 mg/0.05 mL)in this retrospective,comparative,non randomized study.The DME was classified into one of four categories:focal,diffuse,focal cystoid and neurosensory detachment based on OCT.Best corrected visual acuity(BCVA),macular appearance,and OCT findings were used to decide whether the subject should have a repeat injection of intravitreal bevacizumab.Outcome measures were a change in mean BCVA(Snellen converted to logMAR)and central macular thickness(CMT)in each group during the six month follow-up period.RESULTS:The mean BCVA improved to logMAR 0.23at final follow-up from a baseline of 0.32 logMAR(P=0.040)in the focal group,logMAR 0.80 at final follow-up from a baseline of 0.82 logMAR(P=0.838)in the diffuse group,worsened to logMAR 0.53 at final follow-up from a baseline of 0.43 logMAR(P=0.276)in the focal cystoid group,and improved to logMAR 0.79 at final follow-up from a baseline of 0.93 logMAR(P=0.490)in the neurosensory detachment group.The mean CMT before treatment were 298.8±25.03μm in the focal group,310.8±40.6μm in the diffuse group,397.15±31.05μm in the focalcystoid group and 401.03±75.1μm in the neurosensory detachment group.A mean of 2.05(range:1-5)injections in the focal group,1.32(range:1-2)in the diffuse group,2.6(range:1-6)in the focal cystoid group and 2.6(range:1-6)in the neurosensory detachment group were performed during the six month follow-up period.Following intravitreal bevacizumab treatment,vision improved,remained unchanged or worsened in 11,7 and2 subjects in focal group;11,9 and 8 in diffuse group;0,2 and 4 in focal cystoid group and 5,5 and 3 subjects respectively in neurosensory detachment group.CONCLUSION:OCT morpholgy patterns in DME may predict