"PEST control": regulation of molecular barcodes by tyrosine phosphatases

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（9）
• 页码范围: 1027-1028
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.100

摘要

The emerging concept of "molecular barcodes" refers to the dynamic combination of post-translational modifications,often of different nature (e.g.,phosphorylation and ubiquitination) that gives rise to multiple forms of a protein which can relay distinct signals throughout a cell.In a recent Cell Research paper by Wang et al.,the authors report that a PEST domain-containing tyrosine phosphatase,PTPN18,is able to regulate both phosphorylation and ubiquitination of the HER2 oncogene,barcoding HER2 for increased proteasomal degradation rather than for intracellular trafficking.