The aim of this study was to examine the use of bleaching creams containing hydroquinone, corticosteroids and mercury for skin lightening among higher secondary school students in central Sudan. A cross-sectional epidemiological study was conducted at 19 different girls’ schools. A total of 1187 young students aged 16 - 19 years old were randomly selected and approached, using a well-structured questionnaire. The main outcome measure was a number of epidemiological factors per abusers. Results revealed that, 55.4% of the respondents misused this product, whilst 51.6% of girls used cosmetics to lighten their skin for 1 - 3 years with skin irritations prevalence of 3.3%, and the face was reported as main application site (35.4%). In conclusion, the lack of health awareness and ignorance was the main causative factor, whilst education, competent authorities awareness and prescriptions restrictions were highly recommended.