Rbpj links uterine transformation and embryo orientation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（9）
• 页码范围: 1031-1032
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.110

摘要

Implantation involves complex signaling networks,which direct morphological and molecular transformation of the embryo and the uterus and establish the trajectory of normal pregnancy.The recent work by Zhang et al.published in Cell Research,identifies the transcriptional regulator,Rbpj,as essential for uterine closure and proper embryo alignment during implantation in the mouse,raising the possibility that aberrant Rbpj signaling could contribute to infertility in humans.