Spallation target represents one of the most challenging components in accelerator driven systems (ADS) sinceit is the component coupling the accelerator and the sub-critical core. It is subjected to bombardment of intenseproton beam and very high thermal load in a strong radiation field. The irradiated LBE target poses severe handlingproblems for the maintenance staff and other scientists due to its residual activity[1]. To assist the design of ADS, thegeneral radiological safety aspects of lead, lead-bismuth eutectic (LBE) and tungsten spallation target were studiedwith MCNPX 2.7 code[2]. The spallation target was irradiated by a 250 MeV, 10 mA proton beam produced bya linear proton accelerator. The neutron yield, neutron spectrum, residual production and time evolution for theirradiated target were analyzed.