Recent Advances in the Chemistry of Oripavine and Its Derivatives

• 作者: Sandor Hosztafi
• 来源期刊: 生命科学与技术进展(英文)
• 学科: 医学
• 关键词: PAPAVER orientale PAPAVER somniferum Oripavine THEBAINE Top1 POPPY
• 年，卷（期）: 2014,（8）
• 页码范围: 704-717
• 页数: 14页
• 分类号: R73

摘要

Oripavine is the major alkaloid of Papaver orientale. It is an important intermediate in the biosynthesis of morphine alkaloids. Recently, new Papaver somniferum strains have been developed which accumulate thebaine and oripavine, but not morphine and codeine. Therefore, the chemistry of oripavine has been studied intensively to synthesize opioid pharmaceuticals such as oxymorphone, naloxone and buprenorphine.