Good Response to Pemetrexed after Treatment Failure with Another Thymidylate Synthase Inhibitor in Lung Adenocarcinoma: A Case Report

• 作者: Eiko Inamasu Fumihiko Hirai Gouji Toyokawa Kaname Nosaki Masafumi Yamaguchi Mitsuhiro Takenoyama Takashi Seto Tomoyoshi Takenaka Tsukihisa Yoshida Yukito Ichinose
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: PEMETREXED S-1 Thymidylate SYNTHASE
• 年，卷（期）: azzlyw_2014,（8）
• 页码范围: 766-768
• 页数: 3页
• 分类号: R73

摘要

Pemetrexed is an antimetabolic agent and is well-known as a potent inhibitor of thymidylate synthase (TS). It also inhibits dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyl transferase (GARFT). We reported an intriguing case in which a non-small cell lung cancer patient who was refractory to pretreatment with S-1, a strong TS inhibitor, showed good response to pemetrexed treatment.