Cancer signaling: when phosphorylation meets methylation

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（11）
• 页码范围: 1282-1283
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.103

摘要

The propagation of kinase-mediated phosphorylation signals is central to the oncogenic activity of the RAS-MAPK pathway in human cancers.A recent study shows that protein lysine methylation controls the phosphorylation status of a key component of the RAS-MAPK pathway to enable oncogenic KRAS in cancer progression.