An important factor of the physical and chemical properties of solution, pH is the index of hydrogen ionconcentration in solution. When the pH is higher or lower than the fitness value, the enzyme activity of bacteriagrowth and metabolism will decrease, and the metabolism of cell will be blocked, which could cause arrest of growthand affect the cell membrane potential, then the biological function of cell membrane would be changed, and also,the material in and out of cell would be influenced. When the pH of fermented liquid is lower in the produceacid fermentation period, the activity of glutamate dehydrogenase will reduce, and the metabolism of substanceand energy will be in the direction of acetyl glutamine synthesis, which could cause the decline of glutamic acidproductivity.