Activity Induced by a Naphthalene-Prazosin Derivative on Ischemia/Reperfusion Injury in Rats

• 作者: Betty Sarabia-Alcocer Braulio Zepeda-Acosta Eduardo Pool-Gómez Elodia García-Cervera Francisco Díaz-Cedillo Lauro Figueroa-Valverde Lenin Hau-Heredia Marcela Rosas-Nexticapa Rolando García-Martínez
• 来源期刊: 药理与制药(英文)
• 学科: 医学
• 关键词: PRAZOSIN LEFT VENTRICULAR Pressure NIFEDIPINE NAPHTHALENE
• 年，卷（期）: 2014,（12）
• 页码范围: 1130-1142
• 页数: 13页
• 分类号: R73

摘要

In this study, a new naphthalene-prazosin derivative (compound 5) was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of the compound 5 on ischemia/reperfusion injury. Additionally, the mechanism of action involved in the activity exerted by the compound 5 on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds;prazosin, metoprolol, indomethacin and nifedipine. The results showed that the compound 5 reduced infarct size compared with the control conditions. Other results showed that the compound 5 significantly increases (p = 0.05) the perfusion pressure and coronary resistance in isolated rat heart. In addition, other data indicate that the compound 5 increases left ventricular pressure in a dose-dependent manner (0.001 to 100 nM);however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05) and this effect was independent of cAMP levels. In conclusion, these data suggest that the naphthalene-prazosin derivative exerts a cardio protective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in a decrease of myocardial necrosis after ischemia and reperfusion.