Crystal structure of the novel di-nucleotide cyclase from Vibrio cholerae (DncV) responsible for synthesizing a hybrid cyclic GMP-AMP

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（10）
• 页码范围: 1270-1273
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2014.123

摘要

Dear Editor, Through production of cyclic di-nucleotides as second messengers,di-nucleotide cyclases in bacteria and more recently in mammalian cells have been found to play important roles in modulating a wide range of cellular processes [1].During infection of V ibrio cholerae (V.cholerae),di-nucleotide cyclase Vibrio (DncV) is required for efficient intestinal colonization by V.cholerae and downregulates hyperinfectivity-associated V.cholerae chemotaxis through generation of a regulatory molecule cyclic GMP-AMP (cGAMP) [2].