Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（12）
• 页码范围: 1490-1492
• 页数: 3页
• 语种: 中文
• DOI: 10.1038/cr.2014.153

摘要

Dear Editor, Recent discoveries suggest that N6-methyladenosine (m6A) modification,a prevalent internal modification in eukaryotic RNA,is an essential RNA regulatory mechanism.This modification is post-transcriptionally installed by m6A methyltransferases (METTL3-METTL14-WTAP complex) [1-4] and oxidatively removed by m6A demethylases (FTO and ALKBH5) [5,6].These ‘writer' and ‘eraser' enzymes are required for embryo development,energy homeostasis and fertility,suggesting fundamental regulatory roles ofm6A [1,2,5].