Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2014,（12）
• 页码范围: 1493-1496
• 页数: 4页
• 语种: 中文
• DOI: 10.1038/cr.2014.152

摘要

Dear Editor, N6-methyladenosine (m6A) has been demonstrated to be ubiquitous in several types of eukaryotic RNAs,including messenger RNA (mRNA),transfer RNA (tRNA),ribosomal RNA (rRNA),long non-coding RNA (lncRNA),and small nuclear RNA (snRNA) [1].The recent discoveries of RNA m6A methyltransferase complex METTL3/METTL14/WTAP and demethylases FTO and ALKBH5 prove the reversibility of m6A modification [2-6].