In Vivo Magnetic Particle Targeting by Local Gradient Field of Interstitial Seeds Magnetized in an Ex Vivo Uniform Field

• 来源期刊: 中国物理快报（英文版）
• 年，卷（期）: 2014,（2）
• 页码范围: 78-82
• 页数: 5页
• 语种: 英文
• DOI: 10.1088/0256-307X/31/2/024701

摘要

The possibility of in vivo magnetic particle targeting by the locally induced gradient field of interstitial ferromagnetic implants,magnetized in an ex vivo uniform field,is evaluated by a modelling analysis.A simplified 3D model analogous to a torso size,with a continuous laminar flow through the volume with the typical velocity and viscosity values of in vivo blood flow and a ferromagnetic seed inserted in the volume center vertical to the flow,is used to evaluate the magnetic particle capturing efficiency by the seed,which is magnetized in a uniform field.The initial modelling results indicate that for 1 10μm iron oxide particles transporting with a blood flow of 0.5 5 mm/s,the seeds of tungsten steel,magnet steel and cast cobalt all present an effective particle capturing efficiency,which shows a fast initial increase and a slow saturation with the increasing magnetic field,a quasilinear increase with the increasing particle size,and a nonlinear decrease with the increasing blood velocity.