(E)-2-Benzylidenecycloalkanones XII.* Kinetic Measurement of Bovine and Human Serum Albumine Interaction with Selected Chalcones and Their Cyclic Chalcone Analogues by UV Spectrophotometry

• 作者: Beáta Veliká Ivan Kron Krisztina Fodor Pál Perjési Vladimíra Tome?ková
• 来源期刊: 光谱分析(英文)
• 学科: 化学
• 关键词: CHALCONES Cyclic CHALCONE ANALOGUES UV Spectra KINETIC Measurements Binding Constant BOVINE Serum ALBUMIN Human Serum ALBUMIN
• 年，卷（期）: 2015,（1）
• 页码范围: 1-8
• 页数: 8页
• 分类号: O6

摘要

UV-VIS spectroscopic investigations of interaction of bovine and human serum albumin with selected chalcones (1) and their cyclic chalcone analogues: (E)-2-(4’-X-benzylidene-1-tetralones (3), benzosuberones (4) with dimethylamino and methoxy substituents and (E)-2-(2’,4’-dimethox- ybenzylidene)-1-indanone (2) were performed in polar respiration medium. Absorption maxima of the tested compounds were investigated in the presence of bovine and human serum albumin at the 0, 10, 30 and 60 minute timepoints of the interaction. The absorbance of all studied compounds in the presence of proteins decreased after one hour of the reaction. Molecule 4a showed the strongest and fastest kinet initial interaction with both albumins.