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摘要:
A randomized, double blind, and active reference-controlled study was carried out among 116 patients suffering from idiopathic Parkinson’s disease (PD). The aim of the study was to compare the safety and efficacy of alpha-dihydroergocryptine (DHEC) vs. pramipexole (PRAM) as an adjunct symptomatic therapy to levodopa in PD patients. The motor symptoms, assessed by the Unified Parkinson’s Disease Rating Scale (UPDRS) III subscale, was identified as efficacy target. Fifty-six patients were randomized to DHEC and 60 to PRAM. Patients included were under constant levodopa dose for at least 3 months before entering the study, with baseline UPDRS III ≥14. They underwent a 16-week treatment. Out of the 116 included patients, 85 (39 in DHEC group and 46 in PRAM group, respectively) completed the study protocol. In DHEC group, UPDRS III decreased by 24.2% from baseline at week 10 and by 28.1% at week 16. In PRAM group, UPDRS III decreased by 27.1% from baseline at week 10 and by 29.2% at week 16. The data were highly significant (p
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篇名 Alpha-Dihydroergocryptine vs. Pramipexole as Adjunct Symptomatic Treatment of Idiopathic Parkinson’s
来源期刊 帕金森(英文) 学科 医学
关键词 ADJUNCT Symptomatic Therapy Alpha-Dihydroergocryptine PRAMIPEXOLE IDIOPATHIC Parkinson’s Disease Motor Complications UPDRS
年,卷(期) 2015,(1) 所属期刊栏目
研究方向 页码范围 1-8
页数 8页 分类号 R73
字数 语种
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研究主题发展历程
节点文献
ADJUNCT
Symptomatic
Therapy
Alpha-Dihydroergocryptine
PRAMIPEXOLE
IDIOPATHIC
Parkinson’s
Disease
Motor
Complications
UPDRS
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
帕金森(英文)
季刊
2169-9712
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
70
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0
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