Intravascular proliferating anaplastic lymphoma kinasepositive anaplastic large-cell lymphoma

• 作者: Genji Yamaoka Jun-ichiro Kida Kensuke Matsumoto Kohei Shiroshita Makiko Uemura Osamu Imataki Reiji Haba Yumi Miyai
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: Malignant LYMPHOMA CYTOTOXIC molecule INTRAVASCULAR LYMPHOMA ANAPLASTIC LYMPHOMA kinase ANAPLASTIC large-cell LYMPHOMA
• 年，卷（期）: 2015,（2）
• 页码范围: 10-15
• 页数: 6页
• 分类号: R

摘要

An 82-year-old Japanese man visited our emergency unit complaining of dyspnea.Laboratory data showed 15%atypical lymphocytes in peripheral blood which expressed the T-cell phenotype.Chest/abdominal computed tomography depicted hepatosplenomegaly and swelling of systemic lymph nodes.The patient died of advanced respiratory failure 5 d after the first occurrence of his dyspnea.At autopsy,the pathological features revealed a diffuse infiltration of large atypical lymphocytes to systemic organs including the spleen and lung.In immunohistochemical staining,these cells expressed CD30,TIA-1,anaplastic lymphoma kinase(ALK),CD5 and CD3.An advanced surface molecule analysis revealed a lack of CD54(intercellular cell adhesion molecule-1)and CD56(neural cell adhesion molecule).We observed the proliferation and infiltration of these lymphoma cells specifically at the intravascular lesions similar to intravascular lymphoma(IVL).T-cell IVL is not established as an independent clinical entity in the World Health Organization classification,and our patient’s ALK-positive T-IVL in lung appears to be the first reported case.