New biomarkers for clinical management of hepatitis C virus infected patients

• 作者: Alessandra Biasiolo Andrea Martini Patrizia Pontisso
• 来源期刊: 世界临床传染病学杂志
• 学科: 医学
• 关键词: HEPATITIS C VIRUS INFECTION Biomarkers Liver disease PROGRESSION HEPATOCELLULAR carcinoma
• 年，卷（期）: sjlccrbxzz_2015,（4）
• 页码范围: 59-66
• 页数: 8页
• 分类号: R

摘要

Hepatocellular carcinoma(HCC)is the third most frequent oncological cause of death worldwide,principally a consequence of hepatitis C virus(HCV)infection and its prognosis is mostly poor.For early identification and surveillance of HCV patients with liver disease progression,the availability of suitable diagnostic and prognostic biomarkers is still an unmet clinical need.Alfa-fetoprotein together with imaging techniques is commonly used,however its specificity and sensitivity are not satisfactory.Several clinical and serological data have been proposed to define the risk of disease progression in HCV infected patients and new biomarkers have been proposed,including post-transcriptionally modified molecules and genetic biomarkers.The present editorial article attempts to summarize the current knowledge on the new promising tools for effective early diagnosis of HCV-related liver disease progression and for the surveillance of HCC.