Targeting apoptosis is the major battle field for killing cancers

• 作者: Bing Cai Jiang-Ming Gao Jing-Rui Wang Li Liu Shan Liu Shu-Lin Wang Xian-Jun Qu Xiao-Chun Liu
• 来源期刊: 世界转化医学杂志
• 学科: 医学
• 关键词: APOPTOSIS Chemotherapy DRUG targets DRUG resistance Cancer TRANSLATIONAL medicine
• 年，卷（期）: sjzhyxzz_2015,（3）
• 页码范围: 69-77
• 页数: 9页
• 分类号: R

摘要

Targeting apoptosis is one of the major strategies for cancer therapy.Essentially,most of the conventional cancer therapeutic drugs that are in the clinical use induce apoptosis and in part necrosis of malignant cells and therefore prevent cancer progression and metastasis.Although these cytotoxic anticancer drugs are important weapons for killing cancers,their toxic side effects limited their application.The molecularly targeted therapeutics that are based on the deeper understanding of the defects in the apoptotic signaling in cancers are emerging and have shown promising anticancer activity in selectively killing cancers but not normal cells.The examples of molecular targets that are under exploration for cancer therapy include the cell surface receptors such as TNFR family death receptors,the intrinsic Bcl-2 family members and some other intracellular molecules like p53,MDM2,IAP,and Smac.The advance in the high-throughput bio-technologies has greatly accelerated the progress of cancer drug discovery.