Storage lesion:History and perspectives

• 作者: Jean-Daniel Tissot Jean-Jacques Lefrère Julien Delobel Michel Prudent Niels Lion Olivier Garraud Stefano Barelli
• 来源期刊: 世界血液学杂志
• 学科: 医学
• 关键词: Ageing Blood cells EXOSOMES MICROPARTICLES MICROVESICLES PROTEOMICS Storage TRANSFUSION
• 年，卷（期）: 2015,（4）
• 页码范围: 54-68
• 页数: 15页
• 分类号: R

摘要

Red blood cell concentrates(RBCCs)are the major labile blood component transfused worldwide to rescue severe anemia symptoms.RBCCs are frequently stored in additive solutions at 4℃for up to 42 d,which induces cellular lesion and alters red blood cell metabolism,protein content,and rheological properties.There exists a hot debate surrounding the impact of storage lesion,with some uncertainty regarding how RBCC age may impact transfusion-related adverse clinical outcomes.Several studies show a tendency for poorer outcomes to occur in patients receiving older blood products;however,no clear significant association has yet been demonstrated.Some age-related RBCC alterations prove reversible,while other changes are irreversible following protein oxidation.It is likely that any irreversible damage affects the blood component quality and thus the transfusion efficiency.The present paper aims to promote a better understanding of the occurrence of red blood cell storage lesion,with particular focus on biochemical changes and microvesiculation,through a discussion of the historical advancement of blood transfusion processes.