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DNA damage may compromise genome integrity and lead to cell death. Cells have evolved a variety of processes to respond to DNA damage including damage repair and tolerance mechanisms, as well as damage checkpoints. The DNA damage tolerance(DDT) pathway promotes the bypass of single-stranded DNA lesions encountered by DNA polymerases during DNA replication. This prevents the stalling of DNA replication. Two mechanistically distinct DDT branches have been characterized. One is translesion synthesis(TLS) in which a replicative DNA polymerase is temporarily replaced by a specialized TLS polymerase that has the ability to replicate across DNA lesions. TLS is mechanistically simple and straightforward, but it is intrinsically error-prone. The other is the error-free template switching(TS) mechanism in which the stalled nascent strand switches from the damaged template to the undamaged newly synthesized sister strand for extension past the lesion. Error-free TS is a complex but preferable process for bypassing DNA lesions. However, our current understanding of this pathway is sketchy. An increasing number of factors are being found to participate or regulate this important mechanism, which is the focus of this editorial.
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篇名 Mechanism of DNA damage tolerance
来源期刊 世界生物化学杂志:英文版(电子版) 学科 生物学
关键词 DNA DAMAGE tolerance Template switching DNA DAMAGE BYPASS DNA REPLICATION Replicative stress Translesion synthesis UBIQUITINATION SUMOYLATION
年,卷(期) 2015,(3) 所属期刊栏目
研究方向 页码范围 48-56
页数 9页 分类号 Q75
字数 语种
DOI
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研究主题发展历程
节点文献
DNA
DAMAGE
tolerance
Template
switching
DNA
DAMAGE
BYPASS
DNA
REPLICATION
Replicative
stress
Translesion
synthesis
UBIQUITINATION
SUMOYLATION
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界生物化学杂志:英文版(电子版)
季刊
1949-8454
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
391
总下载数(次)
0
总被引数(次)
0
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