Influence of Genetic Polymorphism of Styrene-Metablizing Enzymes on Occupational Exposure Monitoring to Styrene

• 作者: Fang Zhang Wei Qu
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: STYRENE Mandelic ACID (MA) Phenylglyoxylic ACID (PGA) Phenyl Hydroxyethyl Mercapturic Acids (PHEMA) Biological Monitoring Genetic Polymorphisms
• 年，卷（期）: swkxyyxyw_2015,（3）
• 页码范围: 35-38
• 页数: 4页
• 分类号: R73

摘要

In this study, we selected 58 styrene-exposed workers, measured personal styrene exposure, evaluated genotypes relevant drug-metabolizing enzymes (CYP2E1, EPHX1, GSTM1 and GSTT1) which may explain the variability in the urinary metabolite excretion. The results showed that, in different levels of styrene exposure groups, there is a significant association between urinary metabolites and some genotypes of styrene-metabolizing enzymes, including CYP2E1 (5-flanking region, RsaI/PstI), GSTM1(gene deletions) and EPHX1(predicted activity).