Mechanistic insights on immunosenescence and chronic immune activation in HIV-tuberculosis co-infection

• 作者: Adeeba Kamarulzaman Esaki M Shankar Marie Larsson Vijayakumar Velu
• 来源期刊: 世界病毒学杂志
• 学科: 医学
• 关键词: Cluster of differentiation 38 Human IMMUNODEFICIENCY virus-tuberculosis CO-INFECTION IMMUNOSENESCENCE
• 年，卷（期）: 2015,（1）
• 页码范围: 17-24
• 页数: 8页
• 分类号: R

摘要

Immunosenescence is marked by accelerated degradation of host immune responses leading to the onset of opportunistic infections,where senescent T cells show remarkably higher ontogenic defects as compared to healthy T cells.The mechanistic association between T-cell immunosenescence and human immunodeficiency virus(HIV)disease progression,and functional T-cell responses in HIV-tuberculosis(HIV-TB)co-infection remains to be elaborately discussed.Here,we discussed the association of immunosenescence and chronic immune activation in HIV-TB co-infection and reviewed the role played by mediators of immune deterioration in HIV-TB coinfection necessitating the importance of designing therapeutic strategies against HIV disease progression and pathogenesis.