Role of p53 in lung tissue remodeling

• 作者: Harm Jan Bogaard Hirohisa Toga Shiro Mizuno Takeshi Ishizaki
• 来源期刊: 世界呼吸病学杂志
• 学科: 医学
• 关键词: Chronic OBSTRUCTIVE PULMONARY disease PULMONARY hypertension ASTHMA p21 Mouse double MINUTE 2 HOMOLOG
• 年，卷（期）: 2015,（1）
• 页码范围: 40-46
• 页数: 7页
• 分类号: R

摘要

The tumor suppressor gene p53 regulates a wide range of cellular processes including cell cycle progression,proliferation,apoptosis and tissue development and remodeling.Lung cell apoptosis and tissue remodeling have critical roles in many lung diseases.Abnormal proliferation or resistance to apoptosis of lung cells will lead to structural changes of many lung tissues,including the pulmonary vascular wall,small airways and lung parenchyma.Among the many lung diseases caused by vascular cell apoptosis and tissue remodeling are chronic obstructive pulmonary disease,bronchial asthma and pulmonary arterial hypertension.Recent advances in biology and medicine have provided new insights and have resulted in new therapeutic strategies for tissue remodeling in human and animal models.This review is focused on lung disease susceptibility associated with the p53 pathway and describes molecular mechanisms upstream and downstream of p53 in lung tissue remodeling.Improved understanding of structural changes associated with pulmonary vascular remodeling and lung cell apoptosis induced by the p53 pathway may new provide therapeutic targets.