Generalization of the Thermal Dose of Hyperthermia in Oncology

• 作者: Andras Szasz Gyula Vincze Oliver Szasz
• 来源期刊: 生物物理学期刊(英文)
• 学科: 医学
• 关键词: Thermal DOSE Oncothermia Nano-Targeting
• 年，卷（期）: swwlxqkyw_2015,（4）
• 页码范围: 97-114
• 页数: 18页
• 分类号: R73

摘要

Hyperthermia has been a modality to treat cancer for thousands of years. During this time, intensive efforts are concentrated on determining the dose of the proper treatment, but the dominantly in vitro induced cellular death does not provide enough confidence for the clinical dosing. The cell-death by heat-monotherapy applications in laboratory experiments is difficult to apply in the complementary therapies in clinical applications. The newly developed nanotechnologies offer completely new possibilities in this field as well. Modulated electro-hyperthermia (mEHT, trade-name Oncothermia) is a nanoheating technology that has selective effects on membrane rafts and on the transmembrane proteins. This effect is thermal. The thermal action is in nanoscopic range which makes the phenomenon special. Our objective is to show the dose concept on this emerging method.