Dynamic Contrast-Enhanced MRI of Mouse Liver: A Feasibility Study Using a Dual-Input Two-Compartment Tracer Kinetic Model

• 作者: Choon Hua Thng Huynh Hung Kai Hsiang Chuang Septian Hartono Tong San Koh
• 来源期刊: 生物医学工程(英文)
• 学科: 医学
• 关键词: DCE-MRI Mouse Liver IMAGING PRECLINICAL IMAGING
• 年，卷（期）: swyxgcyw,（2）
• 页码范围: 90-97
• 页数: 8页
• 分类号: R73

摘要

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been widely applied to evaluate microcirculatory parameters in clinical settings. However, pre-clinical studies involving DCE-MRI of small animals remain challenging with the requirement for high spatial and temporal resolution for quantitative tracer kinetic analysis. This study illustrates the feasibility of applying a high temporal resolution (2 s) protocol for liver imaging in mice by analyzing the DCE-MRI datasets of mice liver with a dual-input two-compartment tracer kinetic model. Phantom studies were performed to validate the T1 estimates derived by the proposed protocol before applying it in mice studies. The DCE-MRI datasets of mice liver were amendable to tracer kinetic analysis using a dual-input two-compartment model. Estimated micro-circulatory parameters were consistent with liver physiology, indicating viability of applying the technique for pre-clinical drug developments.