Methuselah regulates longevity via dTOR: a pathway revealed by small-molecule ligands

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2015,（3）
• 页码范围: 280-282
• 页数: 3页
• 语种: 中文
• DOI: 10.1093/jmcb/mjv018

摘要

Dear Editor, G protein-coupled receptors (GPCRs), the largest and the most versatile family of membrane receptors, respond to a wide range of extracellular stimuli and control various physiological functions.The potential role of GPCRs in lifespan control has been highlighted by the study in Drosophila with mutations in a class B GPCR encoded by methuselah (mth).Downregulation or mutation of mth increases the lifespan and stress resistanceof Drosophila (Lin et al., 1998).