Functional PET Scan in Four Patients with Higher Order Neglect-Like Cognitive Dysfunction Associated to Chiasm Related Pathology

• 作者: Hans Call? Fledelius Ian Law Kirsten Korsholm
• 来源期刊: 眼科学期刊(英文)
• 学科: 医学
• 关键词: Chiasmal Lesions Visual Field Defects Neglect-Like Behaviour Cognitive Disturbances FUNCTIONAL PET Scan (FDG) of Brain
• 年，卷（期）: 2015,（2）
• 页码范围: 54-60
• 页数: 7页
• 分类号: R73

摘要

Cognitive disturbances with neglect-like features have been reported occasionally in patients with chiasmal disorders, so far however with no obvious substrate by conventional brain imaging. Thus, there were no right hemisphere lesions that could explain the lateralised visual inattention as observed in particular during monocular visual acuity testing. On this background, we further examined four adult patients who consented to functional 18F-fluoro-deoxyglucose (FDG) positron emission tomography (PET) scan. In three there were no significant findings. The fourth patient, a 26-year-old male with cognitive defects after surgery for craniopharyngioma, will be discussed in more detail. His PET scan demonstrated a widespread reduction of regional metabolic activity in left hemisphere primary visual cortex and higher order visual areas, despite absence of explanatory pathological signal changes on MRI. As present in only one out of four patients, however, the findings do not allow specific pathogenetic mechanisms to be suggested, nor generally to substantiate involvement of higher cerebral circuits. Obviously, even developed imaging has its limits, and in the very theory the visual dysfunctions observed might still depend on higher brain centres’ faulty adaptation to loss of pre-geniculate visual information.