基本信息来源于合作网站,原文需代理用户跳转至来源网站获取       
摘要:
The aim of our study was to evaluate functional alterations of the corpus cavernusum and its correlation with the lack of response to treatment with PDE5i in eugonadal patients with Type 2 Diabetes Mellitus and Erectile Dysfunction. In this prospective randomized study we included 157 patients. All were treated with 5 mg tadalafil daily and 100 mg sildenafil on demand and the response to treatment was assessed in 6 month by dividing them into 2 groups: G1: Good response. Significative improvement of erectile function according to IIEF-5, and G2: There was not an improvement with the treatment. At the end of the treatment we performed neurological and vascular studies to both groups. Also we performed CC-EMG in order to evaluate penile autonomic neuropathy. 82 patients were included in G1 and 75 in G2. The time evolution of the ED was 1.5 years for G1 and 5 years for G2. Average fasting glucose and glycosilated hemoglobin values were significantly higher in G2 than in G1. Also we observed significant differences in penile vascular parameters between both groups. Peripheral neuropathy parameters did not show differences between both groups. Cavernous smooth muscle electromyography showed asynchronous and asymetric potentials in G1 (minimal autonomic neuropathy) and denervation potentials in G2 characteristic of severe CC damage. It is concluded that vascular and autonomic alterations are causes of severe CC damage and lack of response to treatment with PDE5i in this population. Peripheral neuropathy is not part of this process.
推荐文章
An experimental study of interaction between pure water and alkaline feldspar at high temperatures a
Alkaline feldspar
Autoclave
High-temperature and high-pressure experiments
A preliminary study on ore-forming environments of Xianglushan-type iron deposit and the weathering
Emeishan basalt paleo-weathering crust
Xianglushan-type iron deposit
Ore-forming environment
Weathering mineralization
Western Guizhou Province
Evaluation of groundwater quality in the Dibdibba aquifer using hydrogeochemical and isotope techniq
Safwan-Zubair
Dibdibba formation
Geochemical modeling
Mixing
Stable isotopes
Basra
内容分析
关键词云
关键词热度
相关文献总数  
(/次)
(/年)
文献信息
篇名 Neurovascular Evaluation in Eugonadal Men with Type 2 Diabetes Mellitus and Erectile Disfunction: A Comparative Study between Responders and Not Responders to Phosphodiesterase 5 Inhibitors
来源期刊 性医学进展(英文) 学科 医学
关键词 Erectile DYSFUNCTION Type 2 Diabetes MELLITUS CORPUS Cavernosum Damage
年,卷(期) 2015,(4) 所属期刊栏目
研究方向 页码范围 83-88
页数 6页 分类号 R5
字数 语种
DOI
五维指标
传播情况
(/次)
(/年)
引文网络
引文网络
二级参考文献  (0)
共引文献  (0)
参考文献  (0)
节点文献
引证文献  (0)
同被引文献  (0)
二级引证文献  (0)
2015(0)
  • 参考文献(0)
  • 二级参考文献(0)
  • 引证文献(0)
  • 二级引证文献(0)
研究主题发展历程
节点文献
Erectile
DYSFUNCTION
Type
2
Diabetes
MELLITUS
CORPUS
Cavernosum
Damage
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
性医学进展(英文)
季刊
2164-5191
武汉市江夏区汤逊湖北路38号光谷总部空间
出版文献量(篇)
82
总下载数(次)
0
期刊文献
论文1v1指导