Inflammation is associated with various cancers, and plays a significant role in prostate cancer genesis including initiation, promotion, malignant conversion, invasion, and metastasis. While several studies posit an important role of inflammation in prostate growth, the exact mechanisms are not known. The extant basic and clinical research in the area, trying to unravel the etiology of prostatic inflammation and its signaling pathway, may help to develop novel therapeutic interventions against prostate cancer development triggered by inflammation.