Pseudouridine in a new era of RNA modifications

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2015,（2）
• 页码范围: 153-154
• 页数: 2页
• 语种: 中文
• DOI: 10.1038/cr.2014.143

摘要

Two articles recently published in Nature and Cell report the first transcriptome-wide maps of pseudouridine (Ψ) at single-base resolution through selective chemical labeling,suggesting new mechanisms and functions ofΨ in mRNA and noncoding RNA molecules. Pseudouridine (Ψ) was among the first post-transcriptional modifications discovered and is overall one of the most abundant [1].It is present in a wide range of cellular RNAs and is highly conserved across species.