Involvement of leak K^+channels in neurological disorders

• 作者: Hiroki Toyoda
• 来源期刊: 世界神经病学杂志
• 学科: 医学
• 关键词: LEAK K^+channel TWIK-related acidsensitive K^+channel NEUROLOGICAL disorder
• 年，卷（期）: sjsjbxzz_2015,（1）
• 页码范围: 52-56
• 页数: 5页
• 分类号: R

摘要

TWIK-related acid-sensitive K+(TASK)channels give rise to leak K+currents which influence the resting membrane potential and input resistance.The wide expression of TASK1 and TASK3 channels in the central nervous system suggests that these channels are critically involved in neurological disorders.It has become apparent in the past decade that TASK channels play critical roles for the development of various neurological disorders.In this review,I describe evidence for their roles in ischemia,epilepsy,learning/memory/cognition and apoptosis.