Nimotuzumab in Treatment of Infiltrating Squamous Cell Carcinoma of Tongue

• 作者: Alex A. Prasad
• 来源期刊: 癌症治疗(英文)
• 学科: 医学
• 关键词: NIMOTUZUMAB EPIDERMAL GROWTH FACTOR Receptor (EGFR) TRANSFORMING GROWTH FACTOR α (TGFα)
• 年，卷（期）: azzlyw,（2）
• 页码范围: 141-145
• 页数: 5页
• 分类号: R73

摘要

A 50-year male patient presented to outpatient department with a mass on tongue associated with pain. A plain computerised tomography scan done on 17/01/13 revealed mild growth on lateral border of tongue with an enlarged jugulo-digastric lymph node measuring 1.8?×?1 cm. Excision of tongue was done and sent for histopathological examination which revealed infiltrating squamous cell carcinoma. The patient was treated with 2 cycles of Induction chemotherapy with cisplatin and paclitaxel administered in q3w schedule. Induction chemotherapy was followed by concurrent chemoradiotherapy with 6 cycles of nimotuzumab 200 mg and cisplatin 20 mg given weekly along with 60 gy/30 fractions of radiation using IMRT. Latest CT scan done on 20/01/2014 revealed no evidence of disease (NED).