Obstructive sleep apnea syndrome and cardiovascular disease:The influence of C-reactive protein

• 作者: Charalampos Mermigkis Eleftherios M Kallergis Eleni Mauroudi Izolde Bouloukaki Sophia E Schiza Violeta Moniaki
• 来源期刊: 世界实验医学杂志
• 学科: 医学
• 关键词: SLEEP APNEA CARDIOVASCULAR C-reactive PROTEIN
• 年，卷（期）: 2015,（2）
• 页码范围: 77-83
• 页数: 7页
• 分类号: R

摘要

Obstructive sleep apnea syndrome(OSAS)is a common medical condition,associated with atherosclerosis and cardiovascular disease(CVD).The underlying pathophysiologic mechanisms of this association have not been completely understood and may be multifactorial in origin.A number of studies suggest that inflammatory processes have emerged critical in the pathogenesis of CVD in OSAS.A range of circulating inflammatory molecules has been identified and measured,with a view to assess inflammation and predict vascular damage risk,such as plasma cytokines,adhesion molecules,and C-reactive protein(CRP).CRP is a relevant marker worthy of further study,because not only is elevated in patients with OSAS,but also is rapidly becoming a risk factor for cardiac disease.Furthermore,in selected OSAS patients,aggressive treatment of the disorder may lead to retarding or even improvement of CVD progression.However,still there is a debate on the true correlation between CRP and OSAS,as well as the clinical effect of any reduction after OSAS treatment.Further research is required to define those OSAS patients who will have a considerable reduction with treatment,as well as to understand the significance of the interaction between cardiovascular risk factor and CRP reduction in patients with OSAS.