Synthesis of New Fluorinated 1,2,4-Triazino [3,4-b][1,3,4]thiadiazolones as Antiviral Probes-Part II-Reactivities of Fluorinated 3-Aminophenyl-1,2,4-triazinothiadiazolone

• 作者: Mohammed Saleh Tawfek Makki Ola Ahmad Abu Ali Reda Mohammady Abdel Rahman
• 来源期刊: 有机化学国际期刊(英文)
• 学科: 化学
• 关键词: Synthesis FLUORINATED 1 2 4-Triazinothiadiazolones ANTHELMINTIC Drugs
• 年，卷（期）: 2015,（3）
• 页码范围: 153-165
• 页数: 13页
• 分类号: O6

摘要

Some new fluorinated 3-N-acyl/3-N-alkylaminophenyl-1,2,4-triazino[3,4-b][1,3,4]thiadiazolones (2-12) have been obtained from treatment of 2-(4'-fluorophenyl)-6-(2'-amino-5'-fluorophenyl)-1,2,4-triazino[3,4-b][1,3,4]thiadiazol-4-one(1) with active functional oxygen, sulfur and halogen compounds in different conditions. Former structures of the products have been characterized from elemental and spectral data (UV, IR, NMR and Mass). The new products were evaluated as potential anthelmintic drugs.