Techniques to elucidate the conformation of prions

• 作者: Martin L Daus
• 来源期刊: 世界生物化学杂志：英文版（电子版）
• 学科: 医学
• 关键词: PRION AMYLOID NEURODEGENERATIVE disease Protein structure FOURIER-TRANSFORM infrared spectroscopy
• 年，卷（期）: 2015,（3）
• 页码范围: 218-222
• 页数: 5页
• 分类号: R373

摘要

Proteinaceous infectious particles(prions) are unique pathogens as they are devoid of any coding nucleic acid.Whilst it is assumed that prion disease is transmitted by a misfolded isoform of the cellular prion protein, the structural insight of prions is still vague and research for high resolution structural information of prions is still ongoing. In this review, techniques that may contribute to the clarification of the conformation of prions are presented and discussed.