Tumor lysis syndrome:A clinical review

• 作者: Aibek E Mirrakhimov Alaa M Ali Maliha Khan Prakruthi Voore
• 来源期刊: 世界重症医学杂志
• 学科: 医学
• 关键词: Cancer ARRHYTHMIA SEIZURE DISORDER Tumor LYSIS syndrome Acute KIDNEY INJURY
• 年，卷（期）: 2015,（2）
• 页码范围: 130-138
• 页数: 9页
• 分类号: R

摘要

Tumor lysis syndrome is an oncometabolic emergency resulting from rapid cell death.Tumor lysis syndrome can occur as a consequence of tumor targeted therapy or spontaneously.Clinicians should stratify every hospitalized cancer patient and especially those receiving chemotherapy for the risk of tumor lysis syndrome.Several aspects of prevention include adequate hydration,use of uric acid lowering therapies,use of phosphate binders and minimization of potassium intake.Patients at high risk for the development of tumor lysis syndrome should be monitored in the intensive care unit.Established tumor lysis syndrome should be treated in the intensive care unit by aggressive hydration,possible use of loop diuretics,possible use of phosphate binders,use of uric acid lowering agents and dialysis in refractory cases.