Imaging and Therapeutic Applications of Optical and Thermal Response of SPION-Based Third Generation Plasmonic Nanodendrimers

• 作者: Maryam Tajabadi Mohammad E. Khosroshahi Shahin Bonakdar
• 来源期刊: 光学与光子学期刊(英文)
• 学科: 化学
• 关键词: SPIONs PAMAM DENDRIMER Gold Nanoparticles Fluorescence BIOIMAGING Therapy
• 年，卷（期）: 2015,（7）
• 页码范围: 212-226
• 页数: 15页
• 分类号: O6

摘要

In this study, 9 nm superparamagnetic iron oxide nanoparticles (SPION) were functionalized by polyamidoamine (PAMAM) dendrimer. Using tetracholoroauric acid (HAuCl4), magnetodendrimer (MD) samples were conjugated by gold nanoparticles (Au-NPs). Two different reducing agents, i.e. sodium borohydride and hydrazine sulfate, and pre-synthesized 10-nm Au-NP were used to evaluate the efficiency of conjugation method. The samples were characterized using X-ray diffractometry (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, UV-visible spectroscopy and fluorescence spectroscopy. The results confirmed that Au- NPs produced by sodium borohydrate and the pre-synthesized 10-nm Au-NPs were capped by MDs whereas the Au-NP prepared by hydrazine sulfate as a reducing agent was entrapped by MDs. Optical properties of the MDs were studied by laser-induced fluorescence spectroscopy (LIF) within a wide range of visible spectrum. Also, based on the thermal analysis, all synthesized nanostructures exhibited a temperature increase using 488 nm and 514 nm wavelengths of a tunable argon laser. The new iron oxide-dendrimer-Au NPs synthesized by sodium borohydrate (IDA- NaBH4) produced the highest temperature increase at 488 nm whereas the other nanostructures particularly pure Au-NPs produced more heating effect at 514 nm. These findings suggest the potential application of these nanocomposites in the field of bioimaging, targeted drug delivery and controlled hyperthermia.