Computational Modelling of Cholera Bacteriophage with Treatment

• 作者: Daniel S. Mgonja Estomih S. Massawe Oluwole Daniel Makinde
• 来源期刊: 流行病学期刊(英文)
• 学科: 数学
• 关键词: CHOLERA BACTERIOPHAGE TREATMENT VIBRIO CHOLERAE Equilibrium Stability Effective REPRODUCTION Number
• 年，卷（期）: 2015,（3）
• 页码范围: 172-186
• 页数: 15页
• 分类号: O1

摘要

This paper examines the computational modelling of cholera bacteriophage with treatment. A nonlinear mathematical model for cholera bacteriophage and treatment is formulated and analysed. The effective reproduction number of the nonlinear model system is calculated by next generation operator method. By using the next generation matrix approach, the disease-free equilibrium is found to be locally stable at threshold parameter less than unity and unstable at threshold parameter greater than unity. Globally, the disease free equilibrium point is not stable due to existence of forward bifurcation at threshold parameter equal to unity. Stability analysis and numerical simulations suggest that the combination of bacteriophage and treatment may contribute to lessening the severity of cholera epidemics by reducing the number of Vibrio cholerae in the environment. Hence with the presence of bacteriophage virus and treatment, cholera is self-limiting in nature.