Based on statistical analysis on the situation of casing damage and water injection pressure in Pubei Oilfield, it shows that the main forms of casing damage in Pubei Oilfield are deformation and dislocation. Dip angle and faults have a significant impact on casing damage and casing damage is closely related to water injection pressure. Through laboratory simulating experiment and theoretical calculation, the formula of critical injection pressure giving rise to casing damage is obtained and the preventive measures are drafted.